The Mechanism of Androgen Deprivation and the Androgen Receptor
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چکیده
منابع مشابه
The Mechanism of Androgen Deprivation and the Androgen Receptor
Prostate cancer is a major cause of cancer-related deaths in American men. The development and growth of prostate cancer depends on the androgen receptor (AR) and its high-affinity binding of dehydrotestosterone (DHT), which derives from testosterone (T). Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors eventually recur and cause death....
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The development and growth of prostate cancer depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors eventually recur and cause death. A critical question is whether the androgen receptor mediates recurrent tumor growth afte...
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Progression of prostate cancer during endocrine therapy is a major clinical problem, the molecular mechanisms of which remain poorly understood. Amplification of the androgen receptor (AR) gene was recently described in recurrent prostate carcinomas from patients who had failed androgen deprivation therapy. To evaluate the hypothesis that amplification of the AR gene is a cause for the failure ...
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ژورنال
عنوان ژورنال: The Open Prostate Cancer Journal
سال: 2010
ISSN: 1876-8229
DOI: 10.2174/1876822901003010047